Characterization of stereospecific enoyl reductase ActVI-ORF2 for pyran ring formation in the actinorhodin biosynthesis of Streptomyces coelicolor A3(2)

Kazuki Ishikawa,Makoto Hashimoto, Kunpei Komatsu,Takaaki Taguchi,Susumu Okamoto,Koji Ichinose

Bioorganic & Medicinal Chemistry Letters（2022）

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摘要

•Heterologous expression of ActVI-ORF2 was established using Rhodococcus erythropolis.•ActVI-ORF2 produces DDHK via enoyl reduction of (S)-DNPA in a stereospecific manner.•ActVI-ORF2 is a discrete NADPH-dependent enoyl reductase.

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关键词

ACT,(S)-DNPA,DDHK,ER,BIQ,MED,GRA,BI,ACP,DMAC,ESI,TSB,PKS,MES,IPR

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