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Structural Basis for Llama Nanobody Recognition and Neutralization of HIV-1 at the CD4-binding Site.

Tongqing Zhou,Lei Chen,Jason Gorman,Shuishu Wang,Young D. Kwon,Bob C. Lin,Mark K. Louder,Reda Rawi,Erik-Stephane D. Stancofski,Yongping Yang,Baoshan Zhang,Anna Forsman Quigley,Laura E. McCoy,Lucy Rutten,Theo Verrips,Robin A. Weiss,Nicole A. Doria-Rose,Lawrence Shapiro,Peter D. Kwong

STRUCTURE（2022）

Cited 6|Views69
Key words
CD4-binding site,cryo-EM,crystal structure,envelope trimer,HIV,llama VHH,nanobody,neutralization,single-domain antibody,steric clash
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