A molecular crowding thermo-switchable chiral G-quartet hydrogel with circularly polarized luminescence property

A novel helix hydrogel with a G-quartet structure was synthesized from guanosine (Gua) and its derivative 5 '-guanosine monophosphate (5 '-GMP) under a molecular crowding environment. The chirality of the hydrogel is adjusted by controlling the gelling speed. The chiral hydrogel can induce an achiral dye Thioflavin T (ThT) to realize circularly polarized fluorescence (CPL). The CPL dissymmetry factor |g(lum)| of the dye-hydrogels can reach 3 x 10(-2) and can be switched easily.