p-Benzoquinone-induced aggregation and perturbation of structure and chaperone function of α-crystallin is a causative factor of cigarette smoke-related cataractogenesis

Aritra Chowdhury,Aparajita Choudhury,Shruti Chakraborty,Arunava Ghosh,Victor Banerjee,Shinjini Ganguly, Gautam Bhaduri,Rajat Banerjee,Kalipada Das,Indu B. Chatterjee

Toxicology（2018）

Cited 8|Views6

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Abstract

•Accumulation of p-benzoquinone is observed in smokers’ lens protein with cataract.•p-benzoquinone causes modification of chaperon function of αA-crystallin.•p-benzoquinone is a causative factor for cigarette smoke-induced cataractogenesis

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Key words

p-Benzoquinone,Cigarette smoke,Cataract,αA-crystallin,Chaperone

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