Nucleolin: a binding partner of G-quadruplex structures

Trends in Cell Biology(2022)

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摘要
Nucleolin protein is involved in a plethora of cellular pathways across the nucleolus, nucleus, and cytoplasm. The association of its RNA-binding domain (RBD) and its RGG (arginine-glycine-glycine-rich) domain allows it to interact with G-quadruplex structures in nucleic acids. We highlight evidence that the nucleolin/G-quadruplex partnership is of extensive relevance to neurodegenerative disease, cancer, and viral infections.
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关键词
nucleolin,G-quadruplex,ligands,interaction
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