KT2 alleviates ulcerative colitis by reducing Th17 cell differentiation through the miR-302c-5p/STAT3 axis

Dandan Gu,Qiong Nan,Yinglei Miao,Hailong Yang,Maojuan Li,Yan Ye,Jiarong Miao

European Journal of Cell Biology（2022）

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摘要

•Antimicrobial peptide KT2 can relieve the symptoms of ulcerative colitis in mice.•Antimicrobial peptide KT2 can inhibit the differentiation of Th17 cells in vitro and in vivo.•Antimicrobial peptide KT2 can up-regulate miR-302c-5p.•MiR-302c-5p targets STAT3 and negatively regulates its expression.

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关键词

Ulcerative colitis,Th17 cell differentiation,KT2,miR-302c-5p,Signal transducer and activator of transcription 3

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