IRF4 suppresses osteogenic differentiation of BM-MSCs by transcriptionally activating miR-636/DOCK9 axis

Xuepu Zhang,Yue Zhang,Limin Yang, Yuexin Wu, Xiaohu Ma, Gang Tong, Zhaoliang Ban,Haosen Zhao

Clinics（2022）

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摘要

•IRF4 is a negative regulator during the osteogenic differentiation of BM-MSCs.•IRF4 can transcriptionally activate microRNA-636 in BM-MSCs.•MicroRNA-636 can suppress the osteogenic differentiationof BM-MSCs by directly targeting DOCK9.

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关键词

Osteoporosis,BM-MSCs,Osteogenic differentiation,miR-636,DOCK9,ALP

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