CCR7 expression in CD19 chimeric antigen receptor-engineered natural killer cells improves migration toward CCL19-expressing lymphoma cells and increases tumor control in mice with human lymphoma

Nathan T Schomer, Ziyue Karen Jiang, Marit I Lloyd,Hans Klingemann,Laurent Boissel

Cytotherapy(2022)

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摘要
Expression of CCR7 receptor by off-the-shelf t-haNK cells improves their homing toward lymph node chemokines both in vitro and in vivo, resulting in superior tumor control.
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关键词
CAR,immunotherapy,lymphoma,migration,NK cells
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