Casticin and chrysosplenol D from Artemisia annua L. induce apoptosis by inhibiting topoisomerase IIα in human non-small-cell lung cancer cells

Phytomedicine(2022)

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摘要
•Casticin (CAS) and chrysosplenol D (CHD) in A. annua showed NSCLC cytotoxicity.•RNA-seq revealed biological processes in A549 cells treated with CAS and CHD.•CAS and CHD induced apoptosis of NSCLC cells by down-regulating topo IIα.
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关键词
Artemisia annua L.,Casticin,Chrysosplenol D,Non-small-cell lung cancer,RNA-seq,Topoisomerase IIα
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