d-mannose administration improves autoimmune hepatitis by upregulating regulatory T cells

Daisuke Ito,Hiroyasu Ito,Takayasu Ideta,Ayumu Kanbe,Masahito Shimizu

Cellular Immunology（2022）

引用 6|浏览2

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摘要

•d-mannose suppresses liver damage in a mouse model of autoimmune hepatitis.•d-mannose induces Treg cells through activation of TGF-β1.•Induction of Treg cells by d-mannose depends on IDO1.

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关键词

d-mannose,Regulatory T cell (Treg),Autoimmune hepatitis (AIH),Inflammation,Concanavalin A (ConA),α-Galactosylceramide (GalCer),Indoleamine 2,3-dioxygenase (IDO)

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