Clinical and molecular implications of RGS2 promoter genetic variation in severe asthma

Juan Carlos Cardet,Donghwa Kim,Eugene Bleecker,Thomas Casale,Elliot Israel,David Mauger,Deborah Meyers,Yaping Tu,Stephen Liggett,Victor Ortega

Journal of Allergy and Clinical Immunology（2022）

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摘要

RGS2 promoter variation associates with a molecular and clinical phenotype characterized by enhanced bronchoconstrictive stimulation in vitro and higher asthma exacerbations rates in non-Hispanic White patients.

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关键词

Regulator of G protein signaling,G protein–coupled receptors,airway hyperresponsiveness,bronchoconstriction,asthma exacerbations,genomics,genotype,airway smooth muscle,phenotype,endotype

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