MDM2 analysis in the management of benign lipomas versus atypical lipomatous tumors/well-differentiated liposarcomas: A useful prognostication tool?

•With upfront marginal resection of truncal or extremities atypical lipomatous tumors/well-differentiated liposarcomas, overall local recurrence rate of 1.4% and reoperation rate of 1.1% were achieved.•When tumors showed MDM2 amplification, local recurrence rate of 6.1% was found as opposed to 0.8% in tumors with no MDM2 amplification.•There was no dedifferentiation or metastasis found with local recurrence.