The interleukin-1 axis and the tumor immune microenvironment in pancreatic ductal adenocarcinoma

Kelly M Herremans,Dominique D Szymkiewicz,Andrea N Riner,Riley P Bohan,Gerik W Tushoski,Aaron M Davidson,XiangYang Lou,Man Chong Leong,Bayli DiVita Dean,Michael Gerber,Patrick W Underwood,Song Han,Steven J Hughes

Neoplasia（2022）

引用 10|浏览4

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摘要

•Distinct changes in gene expression of the IL-1 axis are found in PDAC.•IL-1 axis expression is correlated with changes in immune checkpoint proteins.•Changes in the IL-1 axis impact the tumor immune milieu.•Low tumor expression of IL1B is associated with decreased overall survival.

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关键词

Pancreas cancer,Bioinformatics,Immunology,Immune checkpoint,Survival

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