A Screening of Native (Poly)phenols and Gut-Related Metabolites on 3D HCT116 Spheroids Reveals Gut Health Benefits of a Flavan-3-ol Metabolite.

Josep Rubert,Pamela Gatto,Michael Pancher,Viktoryia Sidarovich,Claudio Curti,Pedro Mena,Daniele Del Rio,Alessandro Quattrone,Fulvio Mattivi

Molecular nutrition & food research（2022）

Cited 10|Views16

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Abstract

A chronic exposure to (4R)-5-(3',4'-dihydroxyphenyl)-γ-valerolactone may lead to a reduced CRC risk. Daily intake of monomeric, oligomeric, and polymeric flavan-3-ols may increase the colonic concentrations of this metabolite, and, in turn, this compound may act locally interacting with intestinal epithelial cells, precancerous and cancer cells.

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Key words

3D spheroids,colorectal cancer,flavan-3-ols,gut microbial metabolites,high content imaging

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