Brain morphometric features predict medication response in youth with bipolar disorder: a prospective randomized clinical trial.

Du Lei,Kun Qin,Wenbin Li,Walter H L Pinaya,Maxwell J Tallman,L Rodrigo Patino,Jeffrey R Strawn,David Fleck,Christina C Klein,Su Lui,Qiyong Gong,Caleb M Adler,Andrea Mechelli,John A Sweeney,Melissa P DelBello

Psychological medicine（2022）

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摘要

These findings demonstrate that pre-treatment morphometric measures and acute brain morphometric changes can serve as medication response predictors in pediatric BD. Brain morphometric features may provide promising biomarkers for developing biologically-informed treatment outcome prediction and patient stratification tools for BD treatment development.

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关键词

Deep learning, bipolar disorder, MRI, cortical thickness, treatment, Young Mania Rating Scale

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