Variants in proinflammatory genes IL1RL1, IL1B and IRF4 are associated with overweight in a pediatric Brazilian population

Ana Paula Castro Melo, Helena Mariana Pitangueira Teixeira,Raisa Santos Coelho, Talita Dos Santos De Jesus, Gerson Almeida Queiroz,Hatilla Dos Santos Silva,Yasmim Cristina Ferreira De Almeida,Neuza Maria Alcantara-Neves,Sheila Maria Alvim De Matos, Silvana D'innocenzo,Rita De Cassia Ribeiro Silva,Maurício Lima Barreto,Ryan Dos Santos Costa, Laise Cedraz Pinto,Camila Alexandrina Figueiredo

Gene（2022）

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摘要

•The C allele (rs1071676) and T allele (rs1143639) inIL1B gene increased the risk for overweight almost three folds.•The A allele (rs2287047) in IL1RL1 was associated as protection for overweight and smaller expression in whole blood.•T allele (rs12203592) in IRF4 almost double the risk of overweight by enhancing IRF4 expression•Variants in proinflammatory genes could increase risk of overweight in children.•Variants in the IRF4, L1RL1 and IL1B genes were associated with childhood overweight.

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关键词

ADD,Chr,CI,DOM,eQTL,WHO,T2DM,VAT,IL,TNF-α,CRP,Tregs,VAT,IRF4,IRFs,SNVs,SCAALA,BMI,MAF,PCA,NCBI,HWE,LD,TG

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