Biological activity and ADME/Tox prediction of some 2-substituted benzoxazole derivatives

•Biological activities were assessed a series of (5 or 6)-amino-2- (substituted phenyl and benzyl) benzoxazole derivatives.•TD5 was found cytotoxic on tested cancer cells and was not exhibit either cytotoxic or genotoxic activity in healthy cells.•TD4 was determined only mutagenic derivative.•The methylene bridge at the 2nd position of benzoxazole ring of compounds decreases biological activity.•Bioavailability of compounds according to the QikProp Properties Predictions were in a permissible range.