Proteomic analysis reveals exercise training induced remodelling of hepatokine secretion and uncovers syndecan-4 as a regulator of hepatic lipid metabolism

William De Nardo,Paula M Miotto,Jacqueline Bayliss,Shuai Nie,Stacey N Keenan,Magdalene K Montgomery,Matthew J Watt

Molecular Metabolism（2022）

引用 8|浏览16

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摘要

•Exercise training remodels hepatokine secretion.•Exercise regulated secreted factors improve insulin action in skeletal muscle.•Syndecan-4 (SDC4) is a novel exercise-induced hepatokine.•SDC4 reduces hepatic fatty acid uptake and hepatic steatosis.

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关键词

Exercise,Hepatokine,Syndecan-4,Non-alcoholic fatty liver disease,Hepatic steatosis,Lipid metabolism

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