High expression of Piezo1 induces senescence in chondrocytes through calcium ions accumulation

Xunshan Ren,Bin Li,Changgeng Xu,Huangming Zhuang,Tianrun Lei,Fuze Jiang,Panghu Zhou

Biochemical and Biophysical Research Communications（2022）

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摘要

•Chondrocytes senescence is closely related to osteoarthritis.•Calcium ions accumulation was involved in chondrocytes senescence.•Elevated expression of Piezo1 existed in senescent chondrocytes.•Piezo1 promoted chondrocytes senescence through calcium ions accumulation.

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关键词

Chondrocyte,Piezo1,Calcium,Senescence,Osteoarthritis

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