Cobalt Bromide-Catalyzed Negishi-Type Cross-Coupling of Amides
Organic Letters(2022)
Abstract
Herein, we describe a novel Negishi-type cross-coupling of amides employing only cobalt bromide salt as the catalyst. This original reaction is highly tolerant to various glutarimide amides as well as organozinc coupling partners. These conditions also allow the performance of the cross-coupling reaction in an eco-compatible solvent such as ethyl acetate on a large scale.
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Key words
bromide-catalyzed,negishi-type,cross-coupling
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