Early Plasma Nuclear DNA, Mitochondrial DNA, and Nucleosome Concentrations Are Associated With Acute Kidney Injury in Critically Ill Trauma Patients.

Hilary E Faust,Oluwatosin Oniyide,Yiyue Wang,Caitlin M Forker,Thomas Dunn,Wei Yang,Paul N Lanken,Carrie A Sims,Nadir Yehya,Jason D Christie,Nuala J Meyer,John P Reilly,Nilam S Mangalmurti,Michael G S Shashaty

Critical care explorations（2022）

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摘要

Plasma nucleic acid DAMPs have distinct kinetics and associations with AKI in critically ill trauma patients. nDNA at presentation predicts subsequent AKI and may be amenable to targeted therapies in this population.

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关键词

acute kidney injury,damage-associated molecular pattern,mitochondrial DNA,nuclear DNA,nucleosomes,trauma

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