Shroom3, a Gene Associated with CKD, Modulates Epithelial Recovery after AKI.

Aihua Li,Joanna Cunanan,Hadiseh Khalili,Timothy Plageman,Kjetil Ask,Ahsan Khan,Ashmeet Hunjan,Thomas Drysdale,Darren Bridgewater

Kidney360（2022）

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摘要

These findings establish that Shroom3 is required for epithelial repair and redifferentiation through the organization of actomyosin regulators, and could explain why genetic variants in Shroom3 are associated with CKD and allograft rejection.

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关键词

Shroom3,acute kidney injury,chronic kidney disease,renal tubular epithelial cells

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