Tpo knockout in zebrafish partially recapitulates clinical manifestations of congenital hypothyroidism and reveals the involvement of TH in proper development of glucose homeostasis

Ya Fang,Jia-Ping Wan,Rui-Jia Zhang,Feng Sun,Liu Yang,Shuang-Xia Zhao,Mei Dong,Huai-Dong Song

General and Comparative Endocrinology（2022）

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摘要

•We generated a tpo knockout zebrafish line by CRISPR Cas9.•Most notable phenotypes of tpo-/- mutant fish presented during larvae-to-juvenile transition period.•Tpo-/- mutants showed increased glucose levels during larval stages.

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关键词

Congenital hypothyroidism,Zebrafish,Tpo mutant,Phenotype,Glucose homeostasis

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