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Metabolism and Transporter Based Drug–drug Interaction of Tacrolimus with Nine Co-Medicated Injections

Qing Xu,Feifei Yu, Zhubing Hao,Wei Wu,Yi Sun, Ting Wang, Guodong Li,Qianzhou Lv,Zhuohan Hu

Medicine in drug discovery（2021）

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Abstract
•CYP3A4/5 is metabolism enzyme of tacrolimus by using human liver microsomes.•Tacrolimus was not the substrates of solute carrier (SLC) transporters.•Metabolism-based DDI induce high individual variability of tacrolimus exposure.
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Key words
Drug–drug interaction (DDI),Herb–drug interaction (HDI),Metabolism base DDI,Transporter base DDI,Tacrolimus
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