A convenient synthesis of 3-aryl-5-methylidene-2-thiohydantoins

Maxim E. Kukushkin,Nikita A. Karpov,Dmitry E. Shybanov,Nikolai V. Zyk,Elena K. Beloglazkina

Mendeleev Communications（2022）

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摘要

3-Aryl-5-methylidene-2-thiohydantoins were constructed in one-pot reaction of aryl isothiocyanates and 3-morpholino- alanine in alkaline medium with the subsequent treatment with boiling hydrochloric acid.

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关键词

2-thiohydantoins,exocyclic C=C bond,heterocyclization,isothiocyanates,amino acids

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