NIR responsive nitric oxide nanogenerator for enhanced biofilm eradication and inflammation immunotherapy against periodontal diseases

•All-in-one nanoplatforms optimize the strategy of periodontal disease treatment.•NIR responsive nitric oxide nanogenerator realize dual-functions by aPDT, PTT and gas therapy.•Nitric oxide nanogenerator exhibit excellent antibacterial efficacy and biofilm eradication.•Modulating the inflammatory immunity by suppressing pro-inflammatory factors and the assembly of NLRP3 inflammasome.