Full-route advances via biomimetic and biodegradable ultrasmall-in-nano architectures with radiation-photo synergy

•Construction of biomimetic and biodegradable ultrasmall-in-nano architectures with cell membrane and frameworks.•High tumor accumulation due to camouflage effect, homotypic adhesion, and suitable size.•Radiation-photo synergy originated from radio-radiodynamic and photodynamic-photothermal effects.•Low level retention in reticuloendothelial organs and rapid excretion via urine and feces.