Prediction of Quality-control Degradation Signals in Yeast Proteins

Kristoffer E Johansson,Bayan Mashahreh,Rasmus Hartmann-Petersen,Tommer Ravid,Kresten Lindorff-Larsen

Journal of Molecular Biology（2023）

引用 4|浏览14

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摘要

•Quality control degrons have amino acid compositions that are distinct from non-degrons.•Degrons are enriched in hydrophobic and depleted in negatively charged amino acids.•We developed QCDPred to predict degrons from amino acid sequence.•Peptide amino acid composition partly explains protein abundance and half-life in yeast.

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关键词

Protein quality control,Protein degradation,Degron,Misfolding,Prediction method

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