Association of VKORC1 and CYP2C9 single-nucleotide polymorphisms with warfarin dose adjustment in Saudi patients.

Jasmine Holail, Reem Mobarak, Bandar Al-Ghamdi,Ahmad Aljada,Hana Fakhoury

Drug metabolism and personalized therapy（2022）

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摘要

Similar to other populations, the and gene polymorphisms are significantly associated with warfarin dosage in Saudi patients. The presence of at least one copy of the mutant alleles for -1173C>T, , and is associated with a significant reduction in warfarin maintenance dose.

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关键词

CYP2C9 , VKORC1 ,polymorphism,warfarin

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