Should the control arms of randomized trials have an expiry date?
NATURE REVIEWS CLINICAL ONCOLOGY(2022)
Abstract
Randomized controlled trials (RCTs) are conducted when clinical equipoise between treatment options exists. However, some RCTs in patients with non-small-cell lung cancer continue to use chemotherapy as the control arm several years after chemotherapy was proven inferior to anti-PD-1 antibodies. Here, we highlight why the justifications for using an inferior treatment in the control arm are invalid and offer solutions that are applicable across tumour types.
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Key words
Non-small-cell lung cancer,Randomized controlled trials,Medicine/Public Health,general,Oncology
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