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Imipramine-Induced Cutaneous and Iris Hyperpigmentation: A Case Report and Literature Review.

Nicholas Coffey,Ziad Ali, Joseph Grau

The primary care companion for CNS disorders（2022）

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Abstract
Imipramine is a tricyclic antidepressant with a rare side effect of cutaneous and iris hyperpigmentation. Granular dermal deposits in microscopy appear to be the cause of this discoloration. Treatment primarily focuses on discontinuing imipramine or laser therapy.
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