A (Fab)ulous tool to block efflux
Nature Chemical Biology（2022）
摘要
The cryo-electron microscopy structure of a fluoroquinolone efflux transporter, NorA, in complex with an antibody fragment provides a new strategy whereby peptide inhibitors derived from antibody loops could be used to block antibiotic efflux in a drug-resistant superbug.
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关键词
Microbiology,Peptides,Structural biology,Transporters,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry
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