Dying cell-derived SAM switches off inflammation

NATURE METABOLISM（2022）

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摘要

The clearance of dying cells by macrophages releases mediators that switch off inflammation. Ampomah et al. reveal how an amino acid derived from apoptotic cargo changes the methylation epigenome of macrophages to take the brakes off an ERK-dependent pathway that terminates inflammatory responses.

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关键词

Acute inflammation,Inflammatory diseases,Metabolism,Life Sciences,general

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