The immune microenvironment shapes transcriptional and genetic heterogeneity in chronic lymphocytic leukemia

Clare Sun,Yun-Ching Chen,Aina Martinez Zurita,Maria Joao Baptista,Stefania Pittaluga,Delong Liu,Daniel Rosebrock,Satyen Harish Gohil,Nakhle S. Saba,Theresa Davies-Hill,Sarah E. M. Herman,Gad Getz,Mehdi Pirooznia,Catherine J. Wu,Adrian Wiestner

Blood Advances（2022）

引用 8|浏览45

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摘要

•A distinct minor subpopulation of LN CLL cells is activated, interfaces with the immune milieu, and promotes disease progression.•Clonal evolution primarily occurs in LN and associates with a suppressed T-cell inflammatory response.

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