Baicalin confers hepatoprotective effect against alcohol-associated liver disease by upregulating microRNA-205
International Immunopharmacology(2022)
摘要
•miR-205 exerts hepatoprotective effect against alcohol-associated liver disease (ALD).•miR-205 targets and inhibits importinα5 expression.•Baicalin upregulates miR-205 expression.•Baicalin inhibits importinα5 to repress the activation of NF-κB signaling pathway.•This study provides better understanding of the hepatoprotective effect of baicalin in ALD.
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关键词
Baicalin,Alcohol-associated liver disease,MicroRNA-205,Importinα5,NF-κB signaling pathway,Hepatic TG
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