Dendritic distribution of CDK5 mRNA and p35 mRNA, and a glutamate-responsive increase of CDK5/p25 complex contribute to tau hyperphosphorylation

Toru Tanaka,Sachiyo Ohashi,Akihiko Takashima,Shunsuke Kobayashi

Biochimica et Biophysica Acta (BBA) - General Subjects（2022）

引用 3|浏览7

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摘要

•CDK5 mRNA and p35 mRNA are distributed in dendrites, and translated in response to neural excitation.•Glutamate induces calpain-dependent generation of the CDK5/p25 complex in dendrites.•Hyperphosphorylated tau with AD epitopes is synthesized within dendrites in response to neural excitation.

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关键词

Tau hyperphosphorylation,Dendrites,CDK5 mRNA,p35 mRNA,Translation,Glutamatergic stimulation

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