The design of a randomized, placebo-controlled, dose-ranging trial to investigate the efficacy and safety of the ADAMTS-5 inhibitor S201086/GLPG1972 in knee osteoarthritis
Osteoarthritis and Cartilage Open(2021)
Abstract
Using strict inclusion criteria and leading imaging techniques with stringent quality controls, the ROCCELLA trial will evaluate the efficacy of S201086/GLPG1972 in slowing cartilage loss in participants with knee OA. The selected eligibility criteria should enrich for participants with OA who experience sufficient cartilage loss to allow detection of a substantial treatment effect.
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Key words
Knee osteoarthritis,Cartilage,Clinical trial,Disease modification,Quantitative magnetic resonance imaging,ADAMTS-5 inhibitor
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