Impact of liver fibrosis and clinical characteristics on dose-adjusted serum methadone concentrations.
Journal of addictive diseases(2023)
摘要
Although no correlation was found between the degree of liver stiffness and dose-adjusted serum methadone concentration, close clinical monitoring should be considered, especially among patients with advanced cirrhosis. Still, serum methadone measurements can be considered a supplement to clinical assessments, taking into account intra-individual variations.
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关键词
BMI,CYP genotypes,Opioid agonist treatment,cirrhosis,liver fibrosis,methadone,serum concentrations
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