Utility of Mid-treatment DWI in Selecting Pathological Responders to Neoadjuvant Chemoradiotherapy in Locally Advanced Esophageal Cancer
Journal of gastrointestinal cancer(2022)
摘要
Purpose Pathological complete response correlates with better clinical outcomes in locally advanced esophageal cancer (LA-EC). However, there is lack of prognostic markers to identify patients in the current setting of neoadjuvant chemoradiotherapy (NACRT) followed by surgery. This study evaluates the utility of mid-treatment diffusion-weighted imaging (DWI) in identifying pathological responders of NACRT. Methods Twenty-four patients with LA-EC on NACRT were prospectively recruited and underwent three MRI (baseline, mid-treatment, end-of-RT) scans. DWI-derived apparent diffusion coefficient (ADC) mean and minimum were used as a surrogate to evaluate the treatment response, and its correlation to pathological response was assessed. Results Mid-treatment ADC mean was significantly higher among patients with pathological response compared to non-responders ( p = 0.011). ADC difference (ΔADC) between baseline and mid-treatment correlated with tumor response ( p = 0.007). ADC at other time points did not correlate to pathological response. Conclusion In this study, mid-treatment ADC values show potential to be a surrogate for tumor response in NACRT. However, larger trials are required to establish DW-MRI as a definite biomarker for tumor response.
更多查看译文
关键词
DW-MRI,Locally advanced esophageal cancer,Neoadjuvant chemoradiotherapy,Pathological response,Treatment response
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要