IL-17A mediates pyroptosis via the ERK pathway and contributes to steroid resistance in CRSwNP

Yue Li,Li-Hong Chang,Wei-Qiang Huang,Hong-Wei Bao,Xia Li,Xiao-Hong Chen,Hao-Tian Wu,Zhou-Zhou Yao,Zi-Zhen Huang,Samuel E Weinberg,De-Yu Fang,Ya-Na Zhang,Ge-Hua Zhang

Journal of Allergy and Clinical Immunology（2022）

引用 14|浏览13

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摘要

Elevated IL-17A level promotes pyroptosis in hNECs through the ERK-NLRP3/caspase-1 signaling pathway and contributes to glucocorticoid resistance by affecting glucocorticoid receptor homeostasis in patients with CRSwNP.

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关键词

Epithelial cells,pyroptosis,IL-17A,NLRP3 inflammasome,steroid resistance

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