Doxorubicin induced immune abnormalities and inflammatory responses via HMGB1, HIF1-α and VEGF pathway in progressive of cardiovascular damage

Ahmad Syukri, Budu,Mochammad Hatta,Muzakkir Amir,Mohammad Saifur Rohman,Idar Mappangara,Cahyono Kaelan,Siti Wahyuni,Agussalim Bukhari,Ade Rifka Junita,Muhammad Reza Primaguna,Ressy Dwiyanti,Andini Febrianti

Annals of Medicine and Surgery（2022）

Cited 17|Views9

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Abstract

•The effect of Doxorubicin (DOX) induced cardiovascular damage via several pathways.•Cardiovascular damage can involve HMGB1, HIF-1α, and VEGF.•HMGB1, HIF-1α, and VEGF as a pivotal regulator in DOX-induce cardiomyocyte damage.•HMGB1, HIF-1α, and VEGF in cardiovascular diseases will be predominantly acting through different pathways.

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Key words

DOX,HMGB1,HIF-1α,VEGF,Cardiotoxicity,Cardiovascular disease

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