Anti-CTLA-4 and anti-PD-1 immunotherapies repress tumor progression in preclinical breast and colon model with independent regulatory T cells response

Tristan Rupp,Laurie Genest,David Babin,Christophe Legrand,Marion Hunault,Guillaume Froget,Vincent Castagné

Translational Oncology（2022）

引用 19|浏览4

暂无评分

摘要

•Anti-PD-1 and anti-CTLA-4 induced anti-tumor response in breast cancer mouse model.•Anti-PD-1 and anti-CTLA-4 induced anti-tumor response in colon cancer mouse model.•Anti-CTLA-4 reduced colon cancer–derived lung metastasis formation in a mouse model.•We identified specific T cell response between anti-PD-1 and anti-CTLA-4.

查看译文

关键词

Checkpoint inhibitors,Immunotherapies,Immuno-oncology,Anti-PD-1,Anti-CTLA-4,Syngeneic preclinical models,Metastasis

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要