ARCANE-ROG: Algorithm for reconstruction of cancer evolution from single-cell data using robust graph learning

Akanksha Farswan,Ritu Gupta,Anubha Gupta

Journal of Biomedical Informatics（2022）

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摘要

•Propose ARCANE-ROG, a robust graph learning-based method for single-cell data.•Reconstructs cancer evolution from single-cell DNA data.•ARCANE-ROG has improved cluster assignment and inference on clonal hierarchies.•Leiden algorithm is used to find an optimal number of clusters in the data.•Validated using 1000 simulated datasets of varying sizes and five real datasets.

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关键词

Single-cell DNA,Denoising,Robust PCA,Clonal evolution,Clustering,Single-cell genomics

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