Vaccine-Associated Measles Encephalitis in Immunocompromised Child, California, USA

Cristina Costales,Malaya K. Sahoo,ChunHong Huang,Carolina V. Guimaraes,Donald Born,Lauren Kushner,Hayley A. Gans,Thuy A. Doan,Benjamin A. Pinsky

EMERGING INFECTIOUS DISEASES（2022）

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摘要

We report a fatal case of vaccine-associated measles encephalitis in an immunocompromised child in California, USA. The infection was confirmed by whole-genome RNA sequencing of measles virus from brain tissue. We observed biased matrix-gene hypermutation consistent with persistent measles virus central nervous system infection.

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关键词

California,United States,immunocompromised patient,measles,meningitis/encephalitis,stem cell transplant,vaccination,vaccine-preventable diseases,vaccines,viruses

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