Amelioration of oxidative stress utilizing nanoemulsion loaded with bromocriptine and glutathione for the management of Parkinson's disease

Muhammad Usama Ashhar,Preeti Vyas,Divya Vohora,Pravat Kumar Sahoo,Kuldeep Nigam,Shweta Dang,Javed Ali,Sanjula Baboota

International Journal of Pharmaceutics（2022）

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摘要

•Oxidative stress has been implicated in the pathogenesis of PD.•Nanoemulsion loaded with BRM and GSH showed enhanced permeation capability.•The antioxidant potential of BRM and GSH was revealed using nanoemulsion.•The antioxidant activity of nanoemulsion was increased after intranasal delivery.

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PD,BRM,GSH,CLSM,SOD,CAT,TBARS,IL-6,TNF-α,ROS,MAO,CNS,BBB,PEG,H & E,DPPH,TBA,DTNB,EDTA,TCA,H2O2,AUC,DTE,DTP

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