CD4(+) CAR T cells persist long-term CD4(+) chimeric antigen receptor T cells in for the long journey

IMMUNOLOGY AND CELL BIOLOGY(2022)

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摘要
In a recently published article, Melenhorst et al. performed a longitudinal analysis on chimeric antigen receptor (CAR) T cells isolated from patients over 10 years after therapy, revealing expansion of a long-lived CD4(+) CAR T-cell population with a cytotoxic phenotype.
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关键词
chimeric antigen receptor T cells, cytotolytic CD4(+) T cells, persistence
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