Apocynin-tandospirone derivatives demonstrate antioxidant properties in the animal model of schizophrenia

•We synthesized new chemicals using apocynin and tandospirone as leading compounds.•New compounds are effective scavengers for intracellular ROS formation induced by X-irradiation in human lymphoma U937 cells.•New compounds reversed the decrease in glutathione levels and reduction of number of PV-positive neurons in the mPFC of rats transiently exposed to MK-801 in the neonatal period.•New compounds may provide a novel therapeutic approach for the treatment of schizophrenia.