Probing the flux of mitochondrial potassium using an azacrown-diketopyrrolopyrrole based highly sensitive probe

G Dinesh Kumar,Marzena Banasiewicz,Antoni Wrzosek,Rafal P Kampa,Manon H E Bousquet,Damian Kusy,Denis Jacquemin,Adam Szewczyk,Daniel T Gryko

Chemical Communications（2022）

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摘要

The diketopyrrolopyrrole bearing an aza-18-crown-6 as a binding unit as well as a PPh3+ group is highly sensitive towards K+ and localizes selectively in mitochondria of cardiac H9C2 cells. Fast efflux/influx of mitochondrial K+ can be observed upon stimulation with nigericin.

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