TRIM66 hastens the malignant progression of non-small cell lung cancer via modulating MMP9-mediated TGF-β/SMAD pathway

Wenyu Chen,Ye Zhang,Zhixian Fang,Weibo Qi,Yufen Xu

Cytokine（2022）

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摘要

•Silencing TRIM66 hindered cell malignant phenotype of non-small cell lung cancer;•TRIM66 interacted with MMP9 in non-small cell lung cancer;•MMP9 activated TGF-β/SMAD pathway;•TRIM66/MMP9/TGF-β/SMAD axis promoted non-small cell lung cancer progression.

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关键词

TRIM66,MMP9,EMT,TGF-β/SMAD pathway,NSCLC,Malignant phenotype

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