Trauma-like exposure alters neuronal apoptosis, Bin1, Fkbp5 and NR2B expression in an amyloid-beta (1-42) rat model of Alzheimer's disease
Neurobiology of Learning and Memory(2022)
Abstract
Post-traumatic stress disorder (PTSD) is a risk factor in the development and progression of Alzheimer's disease (AD), with unclear underlying mechanisms. Recently, we provided data showing the effect of trauma-like stress on Bin1 and Fkbp5 expression in the prefrontal cortex of A beta(1-42) lesioned animals. This present work sought to expand the study by examining the involvement of the amygdala and hippocampus, in addition to highlighting the role of NR2B in the co-occurrence of trauma-like stress and an A beta AD-like pathology.& nbsp;Trauma-like condition was induced by exposing the animals to footshocks. A beta(1-42) was injected into the hippocampus of the animals to induce AD-like pathology. Cognitive functions were assessed in the Morris water maze (MWM) and novel object recognition tests, after which amygdala and hippocampus tissues were harvested for neurochemical analyses.& nbsp;We found that the combination of footshocks and A beta(1-42) lesion caused a decrease in the number of crossings in the target quadrant of the Morris water maze test, indicating memory deficits. Footshocks caused a further downregulation of Bin1 in the amygdala of A beta(1-42)-lesioned rats. Prior exposure to footshocks downregulated NR2B in the hippocampus of A beta(1-42)-lesioned rats. In addition, a combination of footshocks and A beta(1-42) lesion sustained the upregulation of Fkbp5 in the hippocampus and amygdala. A combination of footshocks and A beta(1-42) lesion increased neuronal apoptosis in the hippocampus and amygdala.& nbsp;In conclusion, exposure to a trauma-like condition may influence AD-like pathology, leading to exaggerated behavioural and molecular changes in the amygdala and hippocampus.
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Key words
Post-traumatic stress disorder,Apoptosis,Amyloid-beta,Cognition,Alzheimer's disease
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